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Guanine's electrochemical sensor detects multiple low level pathogens with the mobility of a glucose meter, the simplicity of a pregnancy test, and the accuracy of PCR by binding pathogen targets with millions of electrical detection tags instead of replicating millions of copies. |
Amplified multiplex testing is critical for diagnosing many life-threatening illnesses, particularly those that present with similar symptoms. Unlike other technologies, Guanine can amplify and detect multiple nucleic acid and proteins from the same sample to offer rapid, simple and inexpensive detection with a smart phone adapter. Guanine is ideally suited for:
- Clinical diagnosis such as sepsis pathogen testing in under 1 hour without a culture
- Telehealth and home and community care services to provide mobile testing at the point of collection
- Companion diagnosis that detect nucleic acids and protein analytes from the same sample
- Life science research, genomics, proteomics and precision medicine diagnostics that need to cost-effectively detect and quantify a wide range of biomarkers
- Industrial and environmental pathogens requiring rapid portable testing to prevent outbreaks
- Biodefense for the early detection of biothreats in mobile and infield devices
BREAKTHROUGH DETECTION TECHNOLOGY
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Guanine's patented electrical oligonucleotide detection tags provide a new generation of nucleic acid and protein assays that can detect multiple low level pathogens multiplex with a mobile reader.
When voltage is applied a burst of electrons produces an oxidation peak proportional to the target’s concentration. This allows fast and accurate detection with an inexpensive mobile electrochemical smart phone reader. |
Guanine's patented oligonucleotide tag (synthetic DNA) binds specific detection targets with millions of electroactive molecules on a microparticle. Oligonucleotide tags contain a 70 mer capture sequence for rapid and specific hybridization of genetic targets, and a 20 mer detection sequence from a string of G, A, T or C to produce unique oxidation peaks on a common electrode. Proteins are detected with aptamersor a blend of antibodies and detection oligonucleotides. Multiple electrodes and microparticle conjugates enable high multiplexing from a single sample.
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MOBILE TESTING WITH AI DIAGNOSIS
Guanine enables fast and accurate detection of infective pathogens with an inexpensive mobile smart phone reader. AI tools can be used with the tests to provide a preliminary diagnosis.
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Consumer enters symptoms
on a smart phone, and AI algorithm recommends a specific test if warranted |
Consumer collects sample
and inserts into cartridge that is tested with a smart phone adapter |
AI algorithms provide a
preliminary diagnosis for consumers and doctors who can treat by telehealth |
