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GUANINE INC.
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A new generation of mobile pathogen detection

Guanine's electrochemical sensor detects multiple low level pathogens with the mobility of a glucose meter, the simplicity of a pregnancy test, and the accuracy of PCR by binding pathogen targets with millions of electrical detection tags instead of replicating millions of copies.
Amplified multiplex testing is critical for diagnosing many life-threatening illnesses, particularly those that present with similar symptoms. Unlike other technologies, Guanine can amplify and detect multiple nucleic acid and proteins from the same sample to offer rapid, simple and inexpensive detection with a smart phone adapter. Guanine is ideally suited for:

  • Clinical diagnosis such as sepsis pathogen testing in under 1 hour without a culture
  • Telehealth and home and community care services to provide mobile testing at the point of collection
  • Companion diagnosis that detect nucleic acids and protein analytes from the same sample
  • Life science research, genomics, proteomics and precision medicine diagnostics that need to cost-effectively detect and quantify a wide range of biomarkers
  • Industrial and environmental pathogens requiring rapid portable testing to prevent outbreaks
  • Biodefense for the early detection of biothreats in mobile and infield devices
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BREAKTHROUGH DETECTION TECHNOLOGY
Guanine's patented electrical oligonucleotide detection tags provide a new generation of nucleic acid and protein assays that can detect multiple low level pathogens multiplex with a mobile reader.

When voltage is applied a burst of electrons produces an oxidation peak proportional to the target’s concentration. This allows fast and accurate detection with an inexpensive mobile electrochemical smart phone reader.


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Guanine's patented oligonucleotide tag (synthetic DNA) binds specific detection targets with millions of electroactive molecules on a microparticle. Oligonucleotide tags contain a 70 mer capture sequence for rapid and specific hybridization of genetic targets, and a 20 mer detection sequence from a string of G, A, T or C to produce unique oxidation peaks on a common electrode. Proteins are detected with aptamersor a blend of antibodies and detection oligonucleotides. Multiple electrodes and microparticle conjugates enable high multiplexing from a single sample.

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UPCOMING SEPSIS TEST
Upcoming culture-free sepsis test can identify specific pathogens and drug resistance biomarkers in under 1 hour

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Sepsis Solution
MASSIVE MARKET NEEDS
Infections exceed all other causes of death lead by COVID-19 viral infections and sepsis blood infections

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Market info
PUBLISHED DATA
Positive samples produce a peak signal from oligonucleotide tags proportional to target concentration

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Download publication
LICENSING OPPORTUNITIES
Licensing is available for 3 approved patents covering structures, devices, methods and AI

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licensing opportunities

MOBILE TESTING WITH AI DIAGNOSIS

Guanine enables fast and accurate detection of infective pathogens with an inexpensive mobile smart phone reader. AI tools can be used with the tests to provide a preliminary diagnosis.
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Consumer enters symptoms
on a smart phone, and
AI algorithm recommends
a specific test if warranted

Consumer collects sample
and inserts into cartridge
that is tested with
a smart phone adapter
AI algorithms provide a
preliminary diagnosis for
consumers and doctors who
can treat by telehealth

NEWS

Guanine Inc.'s biosensor with electrochemical oligonucleotide detection tags will be presented at the 3rd International Electronic Conference on Biosensors
March 1, 2023 

announcement
Guanine collaborates with Mount Sinai Innovation Partners
Jan 23, 2023 
Announcement

For more information or to begin a dialog about collaboration please send an email to Guanine

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Copyright 2022 © Guanine Inc. All rights reserved.