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Our electric biosensor will replace slow, tedious and expensive in vitro diagnostics used for complex infections, cancers, neurological and cardiac diseases |
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Our electric biosensor provides comparable results as culture in under 1 hour including viability in a second test |
Our electric biosensor provides comparable results as multiplex PCR plus target concentrations using a mobile reader |
Our electric biosensor provides comparable results as multiplex immunoassays at a fraction of the cost and minimal complexity |
Sepsis blood infections are the greatest cause of
hospital deaths and non-reimbursed costs
Our electric biosensor can reduce the time
for correct sepsis antibiotics from 3 days to 1 hour
hospital deaths and non-reimbursed costs
Our electric biosensor can reduce the time
for correct sepsis antibiotics from 3 days to 1 hour
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Mount Sinai specialists told us what they needed to have
to save lives and improve hospital efficiency wasn't possible with sepsis culture or multiplex PCR tests
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Our upcoming products will allow ER physicians to get antibiotic
type and dose in 1 hour and enable assay developers to develop low cost blood tests for cancer, neurological and cardiac diseases |
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Our electric biosensor quantifies low levels by binding targets
with millions of electric oligonucleotides |
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Low Limit of Detection is attained by attaching targets with millions of
electroactive nucleotides after filter concentration and magnetic separation
electroactive nucleotides after filter concentration and magnetic separation
Our breakthrough electric oligonucleotide will replace optical labels to provide
quantities instead of present/absent for multiple ultra-low level targets
quantities instead of present/absent for multiple ultra-low level targets
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The oligonucleotide is a 20-mer polyguanine sequence that is prefabricated into a highly stable quadruplex, comprising sets of 4 guanine self-assembled into a square planar tetrad stacked between layers of monovalent cations (M+). Guanine-quadruplexes generate an 8-oxoguanine oxidation signal that is stronger than a guanine oxidation signal and is not impacted by noise from captured RNA or DNA fragments.
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Approximately 100 million guanine molecules are delivered on a 3-micron magnetic microparticle and form particle-target-electrode sandwiches on a biosensor. Using filter concentration of a 5 mL sample in advance of lysis and magnetic separation, the electric sensor can attain a limit of detection of 10 – 1000 targets per mL for nucleic acids, proteins, cells and/or small molecules.
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Capture sequences can be fabricated with the polyguanine detection sequence on the same electric oligonucleotide. Antibody ligands can be blended with the electric oligonucleotides on a microparticle. Multiplexing can be done using a 6 x 6 biosensor electrode array. Multiple microparticles with PolyG, PolyA, Poly T and Poly C can be used for detecting 4 different targets on the same electrode.
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Our intellectual property includes electric oligonucleotide
structures, devices, and methods
structures, devices, and methods
Get to know our technology
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PUBLICATION
Detection of Pathogens and Antimicrobial Resistance Genes at Low Concentration via Electrochemical Oligonucleotide Tags Gordon, N., Bawa, R., Palmateer, G. Eng. Proc. (2023), 35, 28. https://doi.org/10.3390/IECB2023-14584 |
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PUBLICATION
Carbapenem-Resistant Enterobacteriaceae Testing in 45 Minutes using Oligonucleotide Detection Tags Gordon, N., Bawa, R., Palmateer, G., Rajabi, M., Gordon J.B., Kotb, N.M., Balasubramaniyam, R, Gordon, B.R. Advances in Medical Imaging, Detection, and Diagnosis. Volume 4, Chapter 26, Jenny Stanford Publishing (2023) |
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Our electric biosensor can be adapted to outperform antiquated biological test instruments and consumables.
Our low cost will drive mass adoption. |
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Send us a message
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Guanine Inc.
7 University Place, Suite B210 Rensselaer, NY 12144-3463 Telephone (514) 813-7936 [email protected] |
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