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Guanine’s multiplex biosensor quantifies low concentration nucleic acids, proteins, small molecules, cells and redox materials in a single assay. Our inexpensive test cartridge and mobile device change detection signal from optic to electric. |
ADVANCED BLOOD TESTS: “ Ultrasensitive detection of circulating tumor DNA or other low-abundance biomarkers in blood could transform cancer diagnostics, but the challenge is to develop cost-effective platforms that maintain high sensitivity without requiring expensive infrastructure."
PRECISION HEALTH AI “ The bottleneck for AI in precision health isn’t the algorithms—it’s the lack of affordable, multiplexed diagnostics that can detect low-concentration molecules like RNAs, proteins, and metabolites in a single assay. Until we solve this, precision medicine will remain a niche.”
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Advanced blood tests for cancer, neurological diseases, cardiac diseases, chronic diseases, complex infections and precision heath AI are too expensive for widespread use. Massive benefits can only be attained by the general population if test costs are drastically reduced. . |
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Our eOligo biosensor inexpensively quantifies multiple low-level nucleic acids, proteins, small molecules, cells and redox targets in a single blood sample as input to AI/ML algorithms. Real-time blood constituent quantities will enhance other information and provide a new generation of precision health interventions. |
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Our upcoming workstation enables assay developers to deliver inexpensive advanced blood tests that can be migrated to mobile test cartridges |
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Blood tests for complex infections take too long for
detecting drug-resistant pathogens and increase mortality,
hospitals stay, and cost per patient by 200% - 300%
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Our upcoming sepsis infection test allows ER physicians
to get antibiotic type and MIC value in 1 hour |
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Guanine stands apart from other electrochemical biosensors
by attaching targets with millions of electric oligonucleotide guanine
molecules per target instead of only 1 tag to detect low concentrations
Our electric oligonucleotide enables multi-analyte quantification,
multiplexing, ultra-low limit of detection, and high sensitivity and specificity
multiplexing, ultra-low limit of detection, and high sensitivity and specificity
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DNA Methylation Our eOligo biosensor can be used to quantify specific genes and associated 5mC and 5hmC without bisulfate conversion, PCR or sequencing |
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on Our predecessor company was spun out from NASA Ames.
We commercialized NASA's carbon nanotube sensor with an automated instrument that
filter concentrated 10L of potable water and then captured target pathogens with magnetic particles
which were magnetically separated in advance of detecting guanine molecules in lysed pathogen RNA.
We commercialized NASA's carbon nanotube sensor with an automated instrument that
filter concentrated 10L of potable water and then captured target pathogens with magnetic particles
which were magnetically separated in advance of detecting guanine molecules in lysed pathogen RNA.
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Our simple third generation platform saves valuable time by attaching targets with magnetic particles bound with ligands and millions of eOligos which form sandwiches on an electrode. eOligos are pre-made into quadruplexes for a stronger 8-oxoguanine detection signal.
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Get to know our technology
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PUBLICATION
Detection of Pathogens and Antimicrobial Resistance Genes at Low Concentration via Electrochemical Oligonucleotide Tags Gordon, N., Bawa, R., Palmateer, G. Eng. Proc. (2023), 35, 28. https://doi.org/10.3390/IECB2023-14584 |
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PUBLICATION
Carbapenem-Resistant Enterobacteriaceae Testing in 45 Minutes using Oligonucleotide Detection Tags Gordon, N., Bawa, R., Palmateer, G., Rajabi, M., Gordon J.B., Kotb, N.M., Balasubramaniyam, R, Gordon, B.R. Advances in Medical Imaging, Detection, and Diagnosis. Volume 4, Chapter 26, Jenny Stanford Publishing (2023) |
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Send us a message
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Guanine Inc.
7 University Place, Suite B210 Rensselaer, NY 12144-3463 Telephone (514) 813-7936 [email protected] |
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