GUANINE INC.
Guanine Electric Biosensor


Our electric biosensor
helps professionals diagnose
complex diseases more quickly
and at a fraction of the cost



 
Our electric biosensor will replace slow, tedious and expensive in vitro diagnostics
used for complex infections, cancers, neurological and cardiac diseases





 
Our electric biosensor provides comparable results as culture in under 1 hour including viability in a second test


Our electric biosensor provides comparable results as multiplex PCR plus target concentrations using a mobile reader

Our electric biosensor provides comparable results as multiplex immunoassays at a fraction of the cost and minimal complexity
Sepsis blood infections are the greatest cause of
hospital deaths and non-reimbursed costs


Our electric biosensor can reduce the time
for correct sepsis antibiotics from 3 days to 1 hour


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Mount Sinai specialists told us what they needed to have
to save lives and improve hospital efficiency
wasn't possible with sepsis culture or multiplex PCR tests


  • Prescribe appropriate antibiotics in 1 hour
  • Assess dozens of pathogens and drug resistance mechanisms
  • Test for blood infections in the ER without a technician
  • Test for blood infections outside of the hospital
  • Transmit results to EMR/EHR and AI algorithms
  • Reduce the cost per sample and instrument
  • Provide quantitative results for future precision medicine



Our upcoming products will allow ER physicians to get antibiotic
type and dose in 1 hour and enable assay developers to develop
low cost blood tests for cancer, neurological and cardiac diseases

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Our electric biosensor inexpensively tests for multiple low-level proteins, nucleic acids (like ctDNA/RNA) and small molecule targets in blood, along with integrated Therapeutic Drug Monitoring to enable a new generation of precision health interventions.

read more
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Our electric biosensor quantifies low levels by binding targets
with millions of
electric oligonucleotides
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Low Limit of Detection is attained by attaching targets with millions of
electroactive nucleotides after filter concentration and magnetic separation


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Our breakthrough electric oligonucleotide will replace optical labels to provide
quantities instead of present/absent for multiple ultra-low level targets


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The oligonucleotide is a 20-mer polyguanine sequence that is prefabricated into a highly stable quadruplex, comprising sets of 4 guanine self-assembled into a square planar tetrad stacked between layers of monovalent cations (M+). Guanine-quadruplexes generate an 8-oxoguanine oxidation signal that is stronger than a guanine oxidation signal and is not impacted by noise from captured RNA or DNA fragments.
Approximately 100 million guanine molecules are delivered on a 3-micron magnetic microparticle and form particle-target-electrode sandwiches on a biosensor. Using filter concentration of a 5 mL sample in advance of lysis and magnetic separation, the electric sensor can attain a limit of detection of 10 – 1000 targets per mL for nucleic acids, proteins, cells and/or small molecules.
Capture sequences can be fabricated with the polyguanine detection sequence on the same electric oligonucleotide. Antibody ligands can be blended with the electric oligonucleotides on a microparticle. Multiplexing can be done using a 6 x 6 biosensor electrode array. Multiple microparticles with PolyG, PolyA, Poly T and Poly C can be used for detecting 4 different targets on the same electrode.
Our intellectual property includes electric oligonucleotide
structures, devices, and methods

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Get to know our technology

PATENT
Bioanalyte Signal Amplification and Detection with Artificial Intelligence Diagnosis.
US 11,105,801
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PATENT
Ultra-Sensitive Bioanalyte Quantification from Self-Assembled Quadruplex Tags.
US 11,175,285
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PUBLICATION
Detection of Pathogens and Antimicrobial Resistance Genes at Low Concentration via Electrochemical Oligonucleotide Tags 
Gordon, N., Bawa, R., Palmateer, G.
Eng. Proc. (2023), 35, 28. https://doi.org/10.3390/IECB2023-14584

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PUBLICATION
Carbapenem-Resistant Enterobacteriaceae Testing in 45 Minutes using Oligonucleotide Detection Tags
Gordon, N., Bawa, R., Palmateer, G., Rajabi, M., Gordon J.B., Kotb, N.M., Balasubramaniyam, R, Gordon, B.R. Advances in Medical Imaging, Detection, and Diagnosis. Volume 4, Chapter 26, Jenny Stanford Publishing (2023)
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Our pedigree evolved from nanotech pioneers, pathogen testing, spearheading a NASA biosensor spinoff and incubating in Mount Sinai's Elementa Labs
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Neil Gordon
B.Eng, MBA

President & CEO
email  LinkedIn

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Raj Bawa
MD, PhD
VP and
Chief IP Officer

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Garry Palmateer M.Sc.
Vice President

Our electric biosensor can be adapted to outperform antiquated biological test instruments and consumables.

Our low cost will drive mass adoption.




 




       
Send us a message

Guanine Inc.

Mail
7 University Place, Suite B210
Rensselaer, NY 12144-3463

Telephone
(514) 813-7936

email
[email protected]

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