Modern diagnostics are constrained not by biology, but by the architectures used to measure it—optical channels, modality-specific instruments, and hardware-defined multiplex limits that fragment workflows and slow iteration.
Guanine addresses this limitation at its root by introducing a new electrochemical signal primitive: an electroactive quadruplex tag engineered to be stackable for low concentration, reversible for repeated interrogation, universal across target types, and pre-conjugatable to magnetic particles for rapid, mobile workflows.
Unlike conventional redox tags or native redox sensing, the quadruplex tag remains chemically intact through repeated measurements—enabling stable, information-dense signal carriers that can be interrogated and separated in software rather than constrained by optics or fixed channels.
This is the foundation of Guanine’s software-defined sensing architecture: multiplexing depth, target identity, and panel composition are encoded algorithmically and decoded from a shared electrochemical measurement space.
Two architectural consequences follow directly from the tag’s reversibility and information density:
In conventional diagnostics, scaling multiplexing requires additional channels, optics, or instruments—driving linear increases in cost and complexity. In Guanine, multiplexing and target identity scale through software because signal separation is encoded electrochemically rather than physically.
This creates a fast path from biomarker discovery to deployed assays—particularly valuable for OEMs and teams seeking to scale assay menus without rebuilding diagnostic stacks.
Guanine’s multi-omic multiplex architecture is a direct consequence of the electroactive reversible quadruplex tag: stackable tagging increases sensitivity, reversibility enables repeated interrogation, and software-defined encoding and waveform control (CME + MDWC) separate and decode dense signal mixtures from complex samples.
Without exposing proprietary algorithms or waveform structures, the key architectural point is simple: Guanine decouples diagnostic scale from modality-specific instruments by shifting multiplexing and identity into software. A compact electrochemical reader becomes a reconfigurable sensing layer—capable of supporting multi-omic panels, time-critical workflows, and OEM rehosting without rebuilding the core infrastructure.
Each pillar strengthens performance, but the differentiation comes from how they integrate around a single signal primitive. The quadruplex tag enables software-defined encoding and waveform control, while magnetic workflows make the architecture practical for rapid, mobile deployment and complex matrices.
Primitive → encoding → waveform control → deployment.
The molecular signal primitive: stable, information-dense carriers engineered for stackability, reversibility, and universal conjugation.
A universal capture-and-signal framework that turns tag stackability into practical sensitivity across biomarker classes.
Software-defined multiplexing: uniquely decodable encoding that scales target identity without optical channelization.
Waveform-domain control that adapts to sample and target behavior—maximizing extraction of meaningful signal in real biological matrices.
Magnetic control that accelerates kinetics and simplifies workflows—critical for rapid, low-infrastructure deployment.
One sensing layer spanning biology: mixed panels and multi-domain readouts without multiple instruments.
Guanine’s IP protects the architectural lock-in mechanism: the electroactive reversible quadruplex tag as a signal primitive, and the software-defined encoding and waveform control it enables. This combination creates high switching costs and makes replication difficult through software or hardware alone.
Selected peer-reviewed and conference publications demonstrating core technology performance.
