IP Available for Licensing

Guanine’s approved patents cover the comprehensive use
of synthetic DNA tags as electrochemical detection structures, and in detection devices, detection methods and AI diagnosis

Guanine's comprehensive patent coverage includes three approved patents

download US 11,105,801

download us 11,175,285

download us 9,624,532

Electrochemically detectable oligonucleotide tag (EC-DOT)
structures in detection

• Single-stranded EC-DOT
• Duplex EC-DOT
• Quadruplex EC-DOT
• Combination EC-DOT/ligand
• Magnetic particle with EC-DOTs
• EC-DOTs comprising guanine adenine, thymine and/or cytosine

Magnetic microparticle conjugate

Deliver millions of EC-DOTs to achieve PCR accuracy without replicating millions of copies

Quadruplex EC-DOT

Increase detection signal by fabricating single-standed guanine sequence into a quadruplex structure (synthetic telomere)

Combination EC-DOT/ligand

Increase detection signal by designing oligonucleotides with both detection sequence and capture sequences

Electrochemically detectable oligonucleotide tag (EC-DOT)
use in detection devices

• Mobile devices
• High throughput lab systems
• Inline production device
• Field node for automating air/water sample collection

Mobile Device Test Cartridge

Single-use test cartridge with on-board reagents

Field Detection Instrument

Automated water sampling and pathogen detection system developed by Guanine's predecessor NASA spin-off

Electrochemically detectable oligonucleotide tag (EC-DOT)
use in detection methods

• Mobile detection methods
• High throughput detection methods

Mobile Detection Methods

EC-DOTs form magnetic particle-target-electrode sandwiches on the surface of a sensor electrode

High Throughput Detection Methods

EC-DOTs are eluted from the sandwich structures and hybridize with complementary recognition probes attached to the surface of a sensor electrode

Integrate Guanine EC-DOT test results with symptoms, rash recognition and patient  assessment algorithms