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Clinicians reviewing rapid sepsis diagnostics
⭐ Time-Aligned Diagnostics for Sepsis Care

Why Sepsis Validates a Software-Defined Diagnostic Architecture

Sepsis compresses the diagnostic challenge into one window:
speed, breadth, and phenotypic confirmation—before clinical decisions are locked in.

Sepsis is medicine’s most time-critical condition. Each hour of delay in effective therapy is associated with an estimated 4–8% increase in mortality, yet today’s diagnostic stacks often return fragmented answers over 24–72 hours—long after critical treatment decisions are made.

This is why sepsis serves as a validation environment for a software-defined sensing architecture: the clinical workflow demands that host response, pathogen + resistance, and phenotypic drug response be measured together—fast enough to guide decisions in the first hours, not days.

Guanine’s architecture delivers time-aligned clinical insight within a single decision window: host response (≈20 min) → pathogen + resistance (≈60 min) → culture-free phenotyping (≈90–120 min).

Guanine rapid sepsis diagnostic timeline (20 / 60 / 90–120 minutes)
Time-aligned workflow designed to deliver actionable insight within the early sepsis decision window.
SEPSIS WHITE PAPER
Sepsis Diagnosis at the Speed of Clinical Decision

Time-aligned diagnostics delivering actionable insight across the first critical hours of sepsis—plus upcoming product configurations.

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Sepsis white paper cover preview
⭐ Why Architecture Matters in Sepsis

One Decision Window Requires One Unified Sensing Layer

What Sepsis Demands

  • Speed fast enough to influence the initial treatment pathway
  • Breadth pathogen + resistance coverage without serial workflows
  • Phenotypic confirmation drug response, not just target detection
  • Unified measurement host response, infection, and therapy in one window
Genotype, phenotype, and host response must be measured together—fast enough to matter.

What Guanine Enables

  • 20 minutes: quantitative host-response markers for early stratification
  • 60 minutes: culture-free pathogen + resistance detection
  • 90–120 minutes: culture-free antimicrobial phenotyping
  • Single architecture: one platform across these domains—without optics or modality-specific stacks
The architecture is designed to deliver complete clinical context within the early decision window.
⭐ Outcome economics hospitals care about

Earlier diagnostic resolution in the first 1–2 hours can enable faster optimization of therapy and better utilization of acute-care resources. The hospital impact is typically evaluated through metrics like:

ICU length of stay
Reduced ICU utilization and days
Hospital LOS
Shorter admissions and throughput gains
Mortality
Earlier effective therapy and escalation
Cost per patient
Lower downstream resource intensity
⭐ Sepsis Configurations

Time-Aligned Diagnostics for Sepsis Care (Upcoming)

Guanine’s sepsis workflow is structured around the clinical decision window—delivering early stratification, broad infectious coverage, and functional drug response without waiting for culture.

Sepsis host response assessment icon

~20-Minute Host-Response Assessment

Rapid quantitative markers to support early recognition and risk stratification—helping teams triage, escalate, and initiate therapy with better context.

Pathogen identification and AMR icon

~60-Minute Pathogen + Resistance

Culture-free identification of pathogens and key resistance targets from the same sample—reducing reliance on serial testing.

  • Broad coverage across Gram-negative / Gram-positive pathogens
  • Supports slow-growing organisms and mixed infections
  • Designed to expand with software-defined panel configuration
Antimicrobial phenotyping icon

~90–120 Minute Culture-Free Phenotyping

Functional antimicrobial response readouts within the early decision window—enabling faster optimization of therapy than culture-dependent workflows.

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⭐ Clinical and Operational Impact

Earlier clarity across the sepsis decision window

Clinical Value

  • Earlier stratification to support triage and escalation
  • Faster infectious clarity to reduce uncertainty in therapy choice
  • Phenotypic confirmation to support optimization and de-escalation
  • Improved stewardship decisioning with earlier evidence

Operational Value

  • Reduced time to appropriate therapy and fewer “trial-and-error” cycles
  • Potential to reduce ICU utilization and overall length of stay
  • Lower downstream cost per patient with earlier resolution
  • Designed for scalable workflows without optical instrument stacks
Sepsis is where architecture must perform—within hours, across domains, and at scale.