SEPSIS
Every hour delay from effective treatment has a 9% drop in patient survival from sepsis shock |
MASSIVE IMPACT ON LIFE AND HEALTHCARE
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Sepsis kills more people than any other medical condition in the US and has a devastating impact worldwide. Each year in the US sepsis causes 270,000 deaths, 1,700,000 cases, $24 B medical costs, $1.6 B litigation payments, 60% re-hospitalization within 12 months with a high incidence of permanent organ damage, cognitive impairment, and physical disability, and the possible progression to sepsis shock with a 50 – 85% mortality.
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OTHER TESTS DON'T DETERMINE DRUG RESISTANCE |
Sepsis can be rapidly diagnosed by analytics and/or protein biomarkers such as Procalcitonin (PCT) and C-reactive protein (CRP). These tests have limited abilities to distinguish sepsis from other inflammatory conditions, to predict outcome, to identify the pathogen-causing the infection or to determine antibiotic resistance. |
Guanine will revolutionize sepsis pathogen testing by eliminating the culture
Guanine's upcoming mobile sepsis test detects specific pathogens and drug resistance biomarkers in 45 minutes without a culture. This will greatly improve sepsis pathogen testing by:
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Guanine detects sepsis pathogens and drug resistance biomarkers by generating oxidation peaks from 4 different oligonucleotide tags (G,A,T.C) on 6 different electrodes. This allows difference sepsis targets to be detected from a single sample including bacteria, fungi, resistance biomakers and even viruses since a culture is not needed.
KPC RNA PERFORMANCE DATA
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Klebsiella pneumoniae carbapenemases (KPCs) RNA from KPC producing Klebsiella pneumoniae and Escherichia coli bacteria are detected in 45 minutes without an overnight culture.
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Rapid and accurate hybridization from 70 sequences that are not restricted by PCR’s 20 sequence limitation
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Guanine’s assay produced a positive signal in 22/22 samples containing KPC-producing K.pneumoniae and a negative signal in 5/6 non KPC-producing K.pneumoniae samples
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Positive signal peaks are
much higher for targets bound by millions of electrical tags |